Basic neurology

Basic Science Seminars in Neurology

C ompared with that of other human pathogens, the proposed replicative cycle of prions is disarmingly simple. It encompasses misfolding of a single protein, the cellular prion protein (PrP), into a disease-associated form called PrP. This is followed by PrP aggregation and possibly fragmentation of aggregates, which may augment the number of replicative units. Although there is no formal proof ...

Basic Science Seminars in Neurology

D espite recent advances in the diagnosis and treatment of multiple sclerosis, we still lack a consensus regarding the causes, pathogenesis, and mechanisms of disease progression. Current evidence indicates that multiple sclerosis is an inflammatory neurodegenerative disorder in which both adaptive and innate immunity play important roles in initiation and maintenance of the disease. Recent evi...

Neurology

tion has a function to fulfill; each phenomenon therefore has a significance. This does not mean that it has a purpose; it was not made as a "part of an intelligent design". Barcroft's book not only makes delightful reading but it is also distinctly useful. In order to understand the bodily functions it is important to memorize the facts of physiology, but this task is made easier if the facts ...

[Neurology].

Aducanumab reduces the burden of amyloid plaques in Alzheimer's disease, with significant improvement of clinical scores. Endovascular thrombectomy is recommended in patients with acute stroke with proximal occlusion of the anterior circulation. CGRP antagonists and botulinum toxin are effective in migraine. ZIKA virus infection has been linked to the Guillain-Barré syndrome. Edaravone has been...

Neurology